منابع مشابه
Alternative genetic pathways in colorectal carcinogenesis.
The comparative typing of matched tumor and blood DNAs at dinucleotide repeat (microsatellite) loci has revealed in tumor DNA the presence of alleles that are not observed in normal DNA. The occurrence of these additional alleles is possibly due to replication errors (RERs). Although this observation has led to the recognition of a subtype of colorectal cancer with a high incidence of RERs (cau...
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The specific etiologic factors and pathogenetic mechanisms, underlying the development of cancers of the colon and rectum appear to be complex and heterogeneous. Despite the continuous advancement in diagnostic and therapeutic methods, despite the global and national programs for prevention it is evidenced increase in colorectal cancer (CRC) incidence and mortality.Further progress is needed in...
متن کاملMolecular Mechanisms of Colorectal Carcinogenesis
K.M. Haigis (ed.), Molecular Pathogenesis of Colorectal Cancer, DOI 10.1007/978-1-4614-8412-7_2, © Springer Science+Business Media New York 2013 Abstract Colorectal cancer (CRC) presents in three major forms: inherited, sporadic, and familial. Although the mechanisms underlying familial CRC are poorly understood, a large body of evidence suggests that inherited and sporadic CRC are caused by se...
متن کاملCellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways.
The interconnectivity between diet, gut microbiota and cell molecular responses is well known; however, only recently has technology allowed the identification of strains of microorganisms harbored in the gastrointestinal tract that may increase susceptibility to cancer. The colonic environment appears to play a role in the development of colon cancer, which is influenced by the human metabolic...
متن کاملStem cells and colorectal carcinogenesis
Colorectal cancer represents an important cause of mortality and morbidity. Unfortunately, the physiopathology is still under study. There are theories about carcinogenesis and it is known that not only a single factor is responsible for the development of a tumor, but several conditions. Stem cells are a promising target for the treatment of colorectal cancer, along with the environment that h...
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ژورنال
عنوان ژورنال: Varna Medical Forum
سال: 2019
ISSN: 2367-5519,1314-8338
DOI: 10.14748/vmf.v8i1.5641